• BGJ398 (NVP-BGJ398): Targeting FGFR Signaling in Cancer a...

  2025-09-23

  Explore the multifaceted applications of BGJ398 (NVP-BGJ398), a selective FGFR1/2/3 inhibitor, in cancer research and developmental biology. This article examines its mechanistic role in apoptosis induction and receptor tyrosine kinase inhibition, with a focus on FGFR-driven malignancies and recent insights from developmental models.

• Torin 1: Advancing mTOR Signaling Pathway Research in Can...

  2025-09-22

  Explore the mechanistic applications of Torin 1, a potent ATP-competitive mTOR inhibitor, in dissecting mTORC1 and mTORC2 signalin

• Torin2 in Apoptosis Research: Dissecting mTOR and RNA Pol...

  2025-09-19

  Explore the use of the highly selective mTOR inhibitor Torin2 in advanced cancer research, focusing on its role in apoptosis assays and its mechanistic interplay with PI3K/Akt/mTOR signaling. This article provides new insights into Torin2's application in dissecting regulated cell death pathways.

• Nonivamide as a TRPV1 Receptor Agonist: Mechanistic Insig...

  2025-09-18

  Explore how Nonivamide, a capsaicin analog and TRPV1 receptor agonist, advances cancer research through apoptosis induction and cancer cell growth inhibition, while also providing new perspectives on inflammation modulation. This article reviews mechanistic findings and experimental best practices for research scientists.

• In addition to plasma membrane sites OCT

  2025-03-03

  

  In addition to plasma membrane sites, OCT3 was also observed associated with endomembranes, including mitochondrial membranes, with particularly strong expression in the outer nuclear membranes of both neurons and astrocytes (Gasser et al., 2017), indicating that, in addition to regulating extracell

• Inhibitors of mPGES are considered as

  2025-03-03

  

  Inhibitors of mPGES-1 are considered as safe alternative to NSAIDs in the treatment of chronic inflammatory diseases that are characterized by excessive PGE2 production (Bahia et al., 2014; Khurana and Jachak, 2016; Koeberle et al., 2016; Korotkova and Jakobsson, 2014; Norberg et al., 2013; Psarra e

• The subdivision of HT receptors started in the s

  2025-03-03

  

  The subdivision of 5-HT receptors started in the 1950s by Gaddum and colleagues, when they realised that in the guinea pig ileum, the effects of 5-HT could be blocked in part by morphine (M), and in part by dibenzyline (D). Gaddum and Picarelli proposed two receptor classes, 5-HT M and 5-HT D (1957)

• br Phosphorylation of P c Initial studies In addition to

  2025-03-03

  

  Phosphorylation of P450c17 – Initial studies In addition to the molar ratio of POR to P450c17 and the allosteric action of cytochrome b5, a third factor that governs 17,20 lyase activity is the serine/threonine (Ser/Thr) phosphorylation of P450c17 itself. In a search for post-translational factor

• Five alternatively spliced isoforms of ATX have

  2025-03-03

  

  Five alternatively-spliced isoforms of ATX have been described and all are catalytically active [16], [17]. The original ATX described in 1992 is termed ATXα, whereas the most abundant isoform is ATXβ and is the same isoform responsible for plasma lysoPLD activity [18]. Full length ATX is synthesize

• br Results br Discussion The A nidulans Aurora kinase displa

  2025-03-03

  

  Results Discussion The A. nidulans Aurora kinase displays diverse locations during mitosis and we show here that it also locates to hyphal regions where septa subsequently form, to the septal pore region of newly formed septa and displays a cas9 protein specific location to mature septa. To i

• br Introduction The process of mitosis is highly complex and

  2025-03-03

  

  Introduction The process of mitosis is highly complex and tightly regulated. This phase of the Malonic acid resulted in two identical daughter cells. The aurora kinases (aurora A, B, and C) are a family of three highly homologous serine-threonine protein kinases that play a key role in regulating

• Apoptosis a major process of programmed cell death and in

  2025-03-01

  

  Apoptosis, a major process of programmed cell death, and in response to many chemopreventive agents (Jeyamohan et al., 2016). In general, two major signaling pathways control apoptosis, namely, a pathway mediated by cell death receptor and a pathway mediated by mitochondrion, and possible drug targe

• F is an orotomide a novel class of antifungals

  2025-03-01

  

  F901318 is an orotomide, a novel class of antifungals, which inhibits pyridine biosynthesis by blocking dihydroorotate dehydrogenase (URA1) activity [137]. Although this pathway is conserved in humans, human URA1 is only 20% identical to its fungal homolog and it is inhibited 2000-fold less effectiv

• Animal fat appears to increase

  2025-03-01

  

  Animal fat appears to increase C. perfringens counts compared with vegetable oil, so there may indeed be some advantage to vegetable diets at least in terms of fat sources (Knarreborg et al., 2002). Small grains such as wheat, rye, oats, and barley, with high levels of non-starch polysaccharides are

• In addition enhanced AT receptor

  2025-03-01

  

  In addition, enhanced AT1 receptor function abnormally increases central and sympathetic activity, contributing to cardiac and renal disease, which in turn alters homeostasis, increases vulnerability to stress, and further injures the brain, and that AT1 receptor blockade ameliorates excessive sympa

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