• In cardiac hypertrophy associated with pathological

  2018-11-12

  

  In cardiac hypertrophy associated with pathological processes, it has been shown that CSCs participate in the reparative processes (Ellison et al., 2013; Leri et al., 2005); however, extensive damage cannot be completely reversed, indicating that the regenerative potential of these stem ACA cost du

• br Resource details br We generated

  2018-11-12

  

  Resource details We generated KCL032 clinical grade hESC line following protocols, established previously (Ilic et al., 2012; Stephenson et al., 2012), and now adapted to cGMP conditions. The expression of the pluripotency markers was tested after freeze/thaw cycle (Fig. 1). Differentiation pot

• miR a has been extensively studied in different

  2018-11-09

  

  miR-29a has been extensively studied in different fields. miR-29a has been reported to be associated with cardiac hypertrophy and fibrosis (Roncarati et al., 2014), and functions as a negative regulator of extracellular matrix remodeling (van Rooij et al., 2008). We have previously reported that miR

• ESC CMs can be subdivided into atrial and ventricular CMs

  2018-11-09

  

  ESC-CMs can be subdivided into atrial and ventricular CMs (Burridge et al., 2012). It has been documented that the expression of the α-isoform of myosin heavy chain (α-MHC), MLC2a, and MLC1a become restricted to the atrium during murine development (Zammit et al., 2000). Here, we employed MLC2a and

• To determine whether the inhibition of RSK and TTK

  2018-11-09

  

  To determine whether the inhibition of RSK and TTK inhibits neovascularization in vivo, we gave mice LL/2 tumor grafts. Both BI-D1870 and AZ3146, used at doses determined to be non-toxic to animals, significantly improved survival, inhibited tumor growth, and decreased vascular density. In contrast,

• br Materials and method br Results Fig shows the age

  2018-11-09

  

  Materials and method Results Fig. 1 shows the age-standardized annual probability of death among U.S-born women aged 45–89 years by U.S. state, where the NLMS data is centered on approximately 1990. It displays the well-documented geographic clustering of especially-high mortality states in th

• In the current study we examined ensemble perception of

  2018-11-09

  

  In the current study, we examined ensemble perception of emotions in autistic children and adolescents, and contrasted these with typical children, adolescents and adults. Autism is a highly heterogeneous neurodevelopmental condition known for difficulties in social interaction and communication. H

• In concordance with data from animal

  2018-11-09

  

  In concordance with data from animal models (Handley et al., 2012) and studies matching for HIV risk factors (Yu et al., 2013), we were unable to identify a consistent HIV-specific fecal dysbiosis pattern after stratifying for HIV transmission group. Yet, HIV-1 infection remained associated with red

• The following are the supplementary

  2018-11-09

  

  The following are the supplementary data related to this article. Potential conflicts of interest Author contributions Acknowledgements This work was supported by the Defense Advanced Research Projects Agency (DARPA) grant N66001-11-1-4180 and the Wyss Institute for Biologically Inspired E

• In our study Small cell lung cancer SCLC accounts for about

  2018-11-09

  

  Small-cell lung cancer (SCLC) accounts for about 15% of all lung tumors and has a 5-year survival below 5%. While SCLC tumors are initially sensitive to chemotherapy, they invariably relapse with a resistant and deadly disease. We and others have found that, contrary to lung adenocarcinomas and squa

• Conversely ECM accumulation in the

  2018-11-09

  

  Conversely, ECM accumulation in the liver is a hallmark of hepatic fibrosis and is associated with hepatic stellate cell activation due to inflammatory signaling (Bataller and Brenner, 2005). ECM reprogramming is necessary for adipose growth and expansion on energy dense diets, and fibrosis in fat t

• We also noticed that there are statistically significant

  2018-11-09

  

  We also noticed that there are statistically significant differences in protein abundance levels depending on the season, or month, the samples were collected. After adjusting our protein abundance levels for storage time and individual age, we found only nominally significant associations with mont

• The ZIKV field is still

  2018-11-09

  

  The ZIKV field is still developing, and critics regarding the use of the original ZIKV strain are starting to emerge. There is currently no appropriate African and Asian reference strains to allow proper comparison of results between laboratories. At this stage, we cannot disregard that the differen

• Results br Discussion This Phase a study of

  2018-11-09

  

  Results Discussion This Phase 2a study of 32 patients is the largest ocular AAV clinical trial to date and serves to confirm the results of the Phase 1 study (Rakoczy et al., 2015), which showed that subretinal injection of rAAV.sFLT-1 is safe. The study also investigates the potential associati

• Together these studies demonstrate that

  2018-11-09

  

  Together these studies demonstrate that while the amygdala plays a role in acquisition, storage and retrieval of fear memory, regulation of fear is dependent on bilateral connections between the amygdala and the vmPFC. Converging evidence has linked anxiety and anxiety-related disorder to impaired f

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