• br Conflicts of interest br

  2022-07-18

  

  Conflicts of interest Significance p53 is required for the induction of cell senescence to limit the proliferation of polyploid cells. We found that Hippo signal deficiency or Yap activation in mouse livers result in polyploid formation and polyploid cell growth. The combined loss of Hippo sig

• Lipid sensing GPCRs as therapeutic targets G protein

  2022-07-16

  

  Lipid-sensing GPCRs as therapeutic targets G-protein-coupled receptors (GPCRs) comprise a family of cell-surface receptors that respond to various extracellular stimuli such as light, odorants, neurotransmitters and hormones, and trigger a cascade of intracellular signaling. There are approximately

• Evaluating the plausibility of this selective scenario is ch

  2022-07-16

  

  Evaluating the plausibility of this selective scenario is challenging because of the uncertainties concerning the biological role of calpain-10 and the significance of its variants with regard to gene function and disease susceptibility. However, from a strictly evolutionary standpoint, our findings

• GPR A a G protein coupled receptor located mainly on

  2022-07-16

  

  GPR109A, a G-protein-coupled receptor located mainly on adipocyte cell membranes, has been identified as the molecular target for nicotinic gemsa sale [[5], [6], [7]] and mediator of NEFA reduction [5]. As a mechanism of NEFA-lowering, it is recognized that activation of GPR109A leads to Gi-mediated

• Consistent with these observations impaired transduction

  2022-07-16

  

  Consistent with these observations, impaired transduction of the glutamate signal by NMDARs (i.e., NMDA receptor hypofunction [NRH]) by parvalbumin-containing GABAergic inhibitory interneurons is implicated in mediating social deficits, a domain of psychopathology responsible for poor functional out

• Introduction Carbohydrates are some of the most stereochemic

  2022-07-16

  

  Introduction Carbohydrates are some of the most stereochemically complex biological molecules found in nature. In addition to their energetic and structural roles in living systems, their role when covalently linked to proteins is critically important in a myriad of molecular recognition processes.

• In this study we find that DH CBD

  2022-07-16

  

  In this study, we find that DH-CBD induces analgesic effects on inflammatory but not acute pain and the N6-Cyclopentyladenosine level of spinal α1 GlyRs increased after CFA paw injection. These results suggest that GlyR α1 is only involved in chronic pain. A possible explanation is that once the exp

• It is an aspiring task to apply the

  2022-07-16

  

  It is an aspiring task to apply the glutamate biosensor for in vivo measurements in Dronedarone tissue. Due to a relatively large size of the electrode used in this work, the biosensor fits only ex vivo applications. However, it is possible to apply platinum microelectrodes 50–100 μm in diameter fo

• br In vivo actions of GLP GLP

  2022-07-16

  

  In vivo actions of GLP-1/GLP-1R agonists on the vascular endothelium Using contrast-enhanced ultrasound, male Sprague Dawley rats receiving an intravenous infusion of native GLP-1 (30 pmol/kg/min) for 2 h demonstrated significant improvements in both microvascular blood volume and microvascular b

• In perimenstrual catamenial epilepsy there is emerging evide

  2022-07-16

  

  In perimenstrual catamenial epilepsy, there is emerging evidence to suggest that P withdrawal plays a key role in seizure exacerbations occurring around the time of menstruation (Backstrom et al., 1984, Bonuccelli et al., 1989, Scharfman and MacLusky, 2006). The mechanisms underlying ovarian cycle-r

• Human GPR hGPR was originally isolated

  2022-07-15

  

  Human GPR55 (hGPR55) was originally isolated in 1999 as an orphan GPCR with high levels of expression in human striatum (Sawzdargo et al., 1999) (Genbank accession # NM_005683.3). hGPR55 was mapped to human chromosome 2q37, and in the human CNS it is predominantly localized to the caudate, putamen,

• FSH and LH are glycoprotein dimers that are comprised

  2022-07-15

  

  FSH and LH, are glycoprotein dimers that are comprised of two subunits, a common α-subunit (αGSU) and a distinct β-subunit (FSHβ or LHβ, respectively), which determines the biological specificity of the gonadotropins (Ciccone and Kaiser, 2009, Gharib et al., 1990). The SBI-0206965 of the gonadotrop

• Here we studied GLUT targeted nanomedicines as a new

  2022-07-14

  

  Here, we studied GLUT1-targeted nanomedicines as a new strategy directed to overcome vascular barrier, enhancing delivery and efficacy in solid tumors. These nanomedicines were prepared by controlled installation of glucose on polymeric micelles incorporating the antitumor agent cisplatin, which is

• br Methods br Results br

  2022-07-14

  

  Methods Results Discussion In this study, we investigated temperature effects on Vj-gating properties of two cardiac GJs. In the case of Cx45 GJs, increased temperature from 22 °C to 28 °C (or 32 °C) led to an accelerated Vj-dependent deactivation with little change in the extent of Vj-gati

• br Introduction Connexins are transmembrane

  2022-07-14

  

  Introduction Connexins are transmembrane proteins that allow the exchange of molecules with the extracellular environment or adjacent Adarotene via channels in the plasma membrane. Intercellular communication and exchange of biologically active molecules, salts, and nutrients to the extracellular

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