• br Acknowledgments This work was supported by grants from th

  2023-05-15

  

  Acknowledgments This work was supported by grants from the “Agence Nationale de la Recherche” ANR-09-CESA-006 program, the Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (Anses, Project n° 2012-2-077) and the Interdisciplinary Program “Longévité et Viei

• Recent studies revealed that certain plant derived

  2023-05-15

  

  Recent studies revealed that certain plant-derived compounds can also interfere with AR function. One way of such an interference is by modulating its expression levels. This is the case for the two flavonoids quercetin and luteolin that have been reported to repress the function of AR by inhibiting

• Adenosine is an endogenous nucleoside that plays pivotal rol

  2023-05-12

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the MK-8745 and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupled receptors

• Adenosine is an endogenous nucleoside that plays pivotal rol

  2023-05-12

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the MK-8745 and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupled receptors

• Adenosine is an endogenous nucleoside that plays pivotal rol

  2023-05-12

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the MK-8745 and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupled receptors

• The benzimidazole group seems to be a

  2023-05-09

  

  The benzimidazole group seems to be a key feature for the excellent anti-tumor activity of galeterone (159), which motivated the synthesis of new steroidal inhibitors containing N-heterocyclic groups structurally related to benzimidazole. Thus, several 1H- and 2H-indazole derivatives of dehydroepian

• Young disease transitioning B Sle mice show

  2023-05-09

  

  Young disease-transitioning B6·Sle1 mice show partial loss of leukocyte Axl versus B6 controls (data not shown). Further, BMDM from diseased B6·Sle1.Yaa mice do not express detectable levels of ADAM10 and TACE (ADAM17) but do express basal levels of Axl similar to wild type B6-derived BMDM (Suppleme

• br Autophagy and antiviral innate immunity signaling br

  2023-05-09

  

  Autophagy and antiviral innate immunity signaling Viral manipulation of autophagy interfering with IFN-I synthesis We have seen that autophagy factors can down-regulate the production of IFN-I induced by RLR engagement during viral infection. In fibroblasts and epithelial cells, there exists c

• Matthew et al synthesized and carried out SAR studies

  2023-05-09

  

  Matthew et al. synthesized and carried out SAR studies of imidazo-[1,2-a]-pyrazine as Aurora kinase inhibitors with enhanced kinase selectivity and found that Piroxicam 39 showed optimal potency on Aurora-A and Aurora-B with IC50 value of 4 nM and 13 nM while on phosphorylation histone H3 (pHH3), E

• In this study we have

  2023-05-09

  

  In this study, we have isolated cabotegravir that encode ACL from G. zeae through random mutagenesis by restriction enzyme-mediated integration (REMI). The mutant Z39P186 where the ACL gene had been disrupted showed defects in vegetative growth, asexual and sexual development, virulence, and trichot

• br Material and methods br Results br Discussion

  2023-05-09

  

  Material and methods Results Discussion Although we were not able to detect 12/15-LOX mRNA in the lungs of 12/15-LOX knockout mice substantial amounts of 15-HETE could be detected in BALF. In fact, significant synthesis of 15-HETE in 12/15-LOX mice have been already reported [17]. The redun

• br Material and methods br Results br Discussion

  2023-05-09

  

  Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential ICG-001 receptor for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacterial enzyme aspara

• In our study caspase and DRAM were

  2023-05-09

  

  In our study, caspase3 and DRAM were identified as being involved in full-length AIFM1-induced apoptosis. Caspase3 is best known for its role in the execution phase of apoptosis in both intrinsic and extrinsic apoptotic pathways [17]. The members of the caspase family are generally in inactive pro-f

• br Roles of apelin and APJ in cardiovascular

  2023-05-09

  

  Roles of apelin and APJ in cardiovascular diseases Therapeutic potential of apelin/APJ in cardiovascular diseases Since the apelin/APJ system plays a key role in the occurrence and development of cardiovascular diseases, it seems logical to presume that targeting this axis should be feasible a

• Since artemisinin shows low solubility and

  2023-05-08

  

  Since artemisinin shows low solubility and poor oral bioavailability [8], [9], derivatizations of artemisinin were carried out and yielded different semisynthetic antimalarial drugs such as artemether and sodium artesunate. Artemether (decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano [4.3-

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