• Post procedural heparin use should be reserved

  2018-11-07

  

  Post-procedural heparin use should be reserved for patients with the highest thromboembolic risk (e.g., patients with mitral or multiple mechanical amphetamine sulfate valves or prior stroke) (Schulman et al., 2015). Given the rapid onset and offset of action of NOACs, no bridging therapy is require

• Our results that pinpoint the G q signaling

  2018-11-07

  

  Our results that pinpoint the Gαq signaling pathway as classificator for the different sepsis courses of patient groups A and B are also supported by a recent GWAS of common variants with respect to the 28-day mortality (Scherag et al., 2016). Among the identified 14 GWAS loci, three are related to

• br Conflicts of Interest br Author Contributions br

  2018-11-07

  

  Conflicts of Interest Author Contributions Acknowledgements Introduction Hepatitis C virus (HCV) is a major global public health problem. Although HCV incidence is declining, morbidity and mortality related to chronic HCV infection are increasing (Aspinall et al., 2015; Kuo et al., 2015)

• br Funding Sources This work was funded through institutiona

  2018-11-07

  

  Funding Sources This work was funded through institutional support from INSERM and by the Agence Nationale pour la Recherche (ANR Blanc 2011, No.: 11-BSV1 005 03, ANR-13-ISV1-0006-01), the Fondation pour la Recherche Médicale (DEQ20140329556), the Programme Hospitalier de Recherche Clinique (PHRC

• HLA transgenic mice are widely used to model the human

  2018-11-07

  

  HLA-transgenic mice are widely used to model the human T cell response in mice. We focused the present study on the HLA B*0702 allele, which is associated with strong T cell response in terms of magnitude and breath (Weiskopf et al., 2013), thereby allowing us to test the role of multiple cross-reac

• br Acknowledgements The authors would

  2018-11-07

  

  Acknowledgements The authors would like to thank Patricia Lemnitzer, Yvonne Jansen, Janine Brauner, and Sebastian Cucuruz for excellent technical assistance. The graphical abstract was designed by Patrick Paulin ([email protected]). We thank Lars König for providing HepG2 cells. Introd

• br Materials and Methods br Results br

  2018-11-07

  

  Materials and Methods Results Discussion Investigations by our group and others have shown differential expression of host genes at the RNA level in peripheral blood in response to ARV infections (Ramilo et al., 2007; Zaas et al., 2009; Woods et al., 2013; Zaas et al., 2013), with heavy rep

• In conclusion the genetic diversity

  2018-11-07

  

  In conclusion, the genetic Phos-tag Acrylamide of P. jirovecii appears limited, suggesting a constant exchange between human individuals and the simultaneous presence of several genotypes in a given individual. On this constant exchange background, some temporal and geographical evolutions of genot

• Annotation of proteins identified by MS

  2018-11-07

  

  Annotation of proteins identified by MS/MS analysis was performed by querying a variety of databases (genomic and transcriptomic) using BLAST (BLASTp, tBLASTn and PSI-BLAST) algorithms [5]. Results are compiled in Supplemental Table S2 and Fasta files containing protein sequences [1]. These files ar

• The past decades have witnessed an era of data

  2018-11-07

  

  The past decades have witnessed an era of data explosion that touches almost every aspects of modern science. Powerful technologies such as Next-gen DNA sequencing, high throughput/content screening platforms, the Large Hadron Collider and more, routinely generate copious amounts of data. At the sam

• First the genotype analysis was done under four inheritance

  2018-11-07

  

  First, the genotype analysis was done under four inheritance models: general genotype model (2 degrees of freedom), additive model (each copy of the minor allele alters the risk in an additive form), dominant model (a single copy of the minor allele is sufficient to modify the risk) and recessive mo

• br Experimental design materials and methods The synthesis w

  2018-11-07

  

  Experimental design, materials and methods The synthesis was carried out as described previously [1]. “Krokodil extract” samples were obtained by the treatment of 4mL of crude “krokodil” with NaOH 20% (m/v) until alkalization, followed by extraction with ethyl acetate. The organic phases were gat

• br Data The data include protein detection of members

  2018-11-07

  

  Data The data include protein detection of members of the PI3K signaling and PIP3 quantification (Figs. 1-3). The detection of respective biomolecules was done with fluorescence immunohistochemistry/immunocytochemistry and Western blot. The analyzed liver sections and primary hepatocytes originat

• ELA causes children to experience their environment

  2018-11-07

  

  ELA causes children to experience their environment as threatening, perceiving themselves as having no value and regarding the future as being not trustworthy (Dube et al., 2003). A history of ELA consequentially increases the risk of developing a psychiatric disorder in adulthood (Rojo-Moreno et al

• On the other hand larger

  2018-11-07

  

  On the other hand, larger volumes in the right ACC have been linked to harm avoidance, a temperamental disposition characterized by excessive worrying, pessimism and shyness, in both genders (Pujol et al., 2002). Women, who are known to be at higher risk for internalizing disorders (McLean et al., 2

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