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The vaccine development approach pursued by
2018-11-01
The vaccine development approach pursued by the GSK Vaccines Institute for Global Health (GVGH) is based on Generalized Modules for Membrane Antigens (GMMA). GMMA are approximately 50nm outer membrane blebs derived from bacteria genetically modified to enhance shedding and to reduce reactogenicity o
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5z br Acknowledgements Many thanks to C
2018-11-01
Acknowledgements Many thanks to C. Johnson for providing unpublished data. This research was supported by an Australian Postgraduate Award and Australian Government Caring for our Country 2 Target Area Grant 2013/14 (Project ID: TAG14-00542) Bettongia tropica population status, viability and impa
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br Conflict of interest statement br
2018-11-01
Conflict of interest statement Acknowledgements We acknowledge support from the National Institute on Drug Abuse, NIH (R21DA022546-01), and the National Institute on Alcohol Abuse and Alcoholism, NIH (R01AA020006-01). We also thank the research assistants and students who helped complete this
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As some of the material in this
2018-11-01
As some of the material in this review is speculative, it is worth being more concrete about specific lines of research to follow up on our suggestions. First, it would be important to establish whether there is indeed a developmental moderation of risk for SAD. More precisely, here, we make the sug
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In terms of substance specific mechanisms of
2018-11-01
In terms of substance-specific mechanisms of action, nicotine facilitates dopaminergic neurotransmission within protease inhibitor cocktail reward pathways via activating nicotinic actylcholine (nAch) receptors, including those located on nerve terminals in VTA projections to the NAcc (D\'souza and
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The DA system undergoes significant reorganization over
2018-11-01
The DA system undergoes significant reorganization over adolescence, which is implicated in the pathophysiology of various disorders that appear during adolescence (see Nelson et al., 2005; Spear, 2000; Wahlstrom et al., 2010a). Across rodents, non-human primates, and humans, increases in dopamine s
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A significant role for interoception in higher
2018-11-01
A significant role for interoception in higher-order cognition is supported by empirical evidence demonstrating that interoceptive ability predicts competence in a variety of emotional domains as well as in learning and decision-making. Within the affective domain, interoception appears to be necess
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In summary our findings suggest that in late childhood and
2018-11-01
In summary, our findings suggest that in late childhood and adolescence, the amPFC and IPL/IPS play a role as integrative regions with high hierarchical positions within the whole-brain network. Furthermore, we showed that disruptions in the hierarchical position of the IPS are associated with psych
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procyanidin b2 br Methods br Results br Discussion In a samp
2018-11-01
Methods Results Discussion In a sample of typically developing community adolescents, those who had engaged in higher risk sexual behaviors differed in neural response and functional connectivity to social reward. Adolescents with higher-risk sexual behavior had greater activation than adol
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br Mathematical model To solve viscous flow problems is to
2018-11-01
Mathematical model To solve viscous flow problems is to solve the Navier–Stokes equations. In this ANA 12 Supplier paper, the Reynolds-averaged Navier–Stokes (RANS) equations and the shear stress transport (SST) model, namely RANS equation method, are used. The SST turbulence model is introduced
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br Experimental design materials and
2018-11-01
Experimental design, materials and methods Acknowledgments Data The dataset presented herein were obtained from the physical and mechanical tests for various volume proportions of staple wire fiber blended with high volume fly ash (HVFA) and cement. The data provides in this article compose
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Here we present the first case in Asia
2018-11-01
Here, we present the first case in Asia of sarcoidosis with bilateral leg lymphedema as the initial presentation. Notably, cutaneous manifestation is common in sarcoidosis. This case reminds us to consider sarcoidosis in the differential diagnosis of leg lymphedema, thereby prompting early diagnosis
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br Materials and methods br
2018-11-01
Materials and methods Results and discussion The nanoparticles of RDX and HMX were precipitated immediately on the injection of their respective solution into antisolvent (water). Stirring was continued up to a few minutes after the injection to complete the mixing to precipitate smaller parti
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In the work of Li and Hui the
2018-11-01
In the work of Li and Hui, the IR thermography method was used to investigate the detonation temperature of certain thermobaric explosives (TBE) [87]. The experimental results have showed that jnk inhibitor the temperature of TBE\'s detonation was higher than that of TNT with the same weight. The d
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La imagen del hermafrodita constituye en s misma la evidenci
2018-11-01
La imagen del hermafrodita constituye en sí misma la evidencia, pero, Tipifarnib fin de que nadie la pusiera en duda, una serie de líneas diagramáticas con números y notas al calce la atraviesan: La mano La mano que impone la verdad del sexo está rodeada de otros textos. Bordeando la imagen apar
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