• The availability of energy resources likely affects

  2018-11-07

  

  The availability of energy resources likely affects the body’s ability to expend effort. One means by which energy is released is through glucose metabolism. Glucose utilization as reflected by plasma glucose levels was reduced during the 24h sleep deprivation period and was associated with decrease

• Sleep deprivation negatively impacts quality of life

  2018-11-07

  

  Sleep deprivation negatively impacts quality of life, affecting the health of the population, and is associated with increased overweight and obesity, higher risk of cardiac and metabolic diseases, as well as greater risk of accidents in the workplace and higher health costs [7–9]. Studies have high

• Otro autor Daniel Innerarity ha conceptualizado

  2018-11-07

  

  Otro autor, Daniel Innerarity (2011), ha conceptualizado esta tendencia contradictoria como la transición hacia una “sociedad del desconocimiento”, esto es: Que esto ocurra, por supuesto no es automático ni mecánico, ni ocurre tan sólo porque niclosamide alguien se le ocurra generar algún tipo de c

• Post procedural heparin use should be reserved

  2018-11-07

  

  Post-procedural heparin use should be reserved for patients with the highest thromboembolic risk (e.g., patients with mitral or multiple mechanical amphetamine sulfate valves or prior stroke) (Schulman et al., 2015). Given the rapid onset and offset of action of NOACs, no bridging therapy is require

• Our results that pinpoint the G q signaling

  2018-11-07

  

  Our results that pinpoint the Gαq signaling pathway as classificator for the different sepsis courses of patient groups A and B are also supported by a recent GWAS of common variants with respect to the 28-day mortality (Scherag et al., 2016). Among the identified 14 GWAS loci, three are related to

• br Conflicts of Interest br Author Contributions br

  2018-11-07

  

  Conflicts of Interest Author Contributions Acknowledgements Introduction Hepatitis C virus (HCV) is a major global public health problem. Although HCV incidence is declining, morbidity and mortality related to chronic HCV infection are increasing (Aspinall et al., 2015; Kuo et al., 2015)

• br Funding Sources This work was funded through institutiona

  2018-11-07

  

  Funding Sources This work was funded through institutional support from INSERM and by the Agence Nationale pour la Recherche (ANR Blanc 2011, No.: 11-BSV1 005 03, ANR-13-ISV1-0006-01), the Fondation pour la Recherche Médicale (DEQ20140329556), the Programme Hospitalier de Recherche Clinique (PHRC

• HLA transgenic mice are widely used to model the human

  2018-11-07

  

  HLA-transgenic mice are widely used to model the human T cell response in mice. We focused the present study on the HLA B*0702 allele, which is associated with strong T cell response in terms of magnitude and breath (Weiskopf et al., 2013), thereby allowing us to test the role of multiple cross-reac

• br Acknowledgements The authors would

  2018-11-07

  

  Acknowledgements The authors would like to thank Patricia Lemnitzer, Yvonne Jansen, Janine Brauner, and Sebastian Cucuruz for excellent technical assistance. The graphical abstract was designed by Patrick Paulin ([email protected]). We thank Lars König for providing HepG2 cells. Introd

• br Materials and Methods br Results br

  2018-11-07

  

  Materials and Methods Results Discussion Investigations by our group and others have shown differential expression of host genes at the RNA level in peripheral blood in response to ARV infections (Ramilo et al., 2007; Zaas et al., 2009; Woods et al., 2013; Zaas et al., 2013), with heavy rep

• In conclusion the genetic diversity

  2018-11-07

  

  In conclusion, the genetic Phos-tag Acrylamide of P. jirovecii appears limited, suggesting a constant exchange between human individuals and the simultaneous presence of several genotypes in a given individual. On this constant exchange background, some temporal and geographical evolutions of genot

• Annotation of proteins identified by MS

  2018-11-07

  

  Annotation of proteins identified by MS/MS analysis was performed by querying a variety of databases (genomic and transcriptomic) using BLAST (BLASTp, tBLASTn and PSI-BLAST) algorithms [5]. Results are compiled in Supplemental Table S2 and Fasta files containing protein sequences [1]. These files ar

• The past decades have witnessed an era of data

  2018-11-07

  

  The past decades have witnessed an era of data explosion that touches almost every aspects of modern science. Powerful technologies such as Next-gen DNA sequencing, high throughput/content screening platforms, the Large Hadron Collider and more, routinely generate copious amounts of data. At the sam

• First the genotype analysis was done under four inheritance

  2018-11-07

  

  First, the genotype analysis was done under four inheritance models: general genotype model (2 degrees of freedom), additive model (each copy of the minor allele alters the risk in an additive form), dominant model (a single copy of the minor allele is sufficient to modify the risk) and recessive mo

• br Experimental design materials and methods The synthesis w

  2018-11-07

  

  Experimental design, materials and methods The synthesis was carried out as described previously [1]. “Krokodil extract” samples were obtained by the treatment of 4mL of crude “krokodil” with NaOH 20% (m/v) until alkalization, followed by extraction with ethyl acetate. The organic phases were gat

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