• The following are the supplementary

  2018-11-09

  

  The following are the supplementary data related to this article. Potential conflicts of interest Author contributions Acknowledgements This work was supported by the Defense Advanced Research Projects Agency (DARPA) grant N66001-11-1-4180 and the Wyss Institute for Biologically Inspired E

• In our study Small cell lung cancer SCLC accounts for about

  2018-11-09

  

  Small-cell lung cancer (SCLC) accounts for about 15% of all lung tumors and has a 5-year survival below 5%. While SCLC tumors are initially sensitive to chemotherapy, they invariably relapse with a resistant and deadly disease. We and others have found that, contrary to lung adenocarcinomas and squa

• Conversely ECM accumulation in the

  2018-11-09

  

  Conversely, ECM accumulation in the liver is a hallmark of hepatic fibrosis and is associated with hepatic stellate cell activation due to inflammatory signaling (Bataller and Brenner, 2005). ECM reprogramming is necessary for adipose growth and expansion on energy dense diets, and fibrosis in fat t

• We also noticed that there are statistically significant

  2018-11-09

  

  We also noticed that there are statistically significant differences in protein abundance levels depending on the season, or month, the samples were collected. After adjusting our protein abundance levels for storage time and individual age, we found only nominally significant associations with mont

• The ZIKV field is still

  2018-11-09

  

  The ZIKV field is still developing, and critics regarding the use of the original ZIKV strain are starting to emerge. There is currently no appropriate African and Asian reference strains to allow proper comparison of results between laboratories. At this stage, we cannot disregard that the differen

• Results br Discussion This Phase a study of

  2018-11-09

  

  Results Discussion This Phase 2a study of 32 patients is the largest ocular AAV clinical trial to date and serves to confirm the results of the Phase 1 study (Rakoczy et al., 2015), which showed that subretinal injection of rAAV.sFLT-1 is safe. The study also investigates the potential associati

• Together these studies demonstrate that

  2018-11-09

  

  Together these studies demonstrate that while the amygdala plays a role in acquisition, storage and retrieval of fear memory, regulation of fear is dependent on bilateral connections between the amygdala and the vmPFC. Converging evidence has linked anxiety and anxiety-related disorder to impaired f

• Collapsed across groups vACC activation did not show a signi

  2018-11-09

  

  Collapsed across groups, vACC activation did not show a significant correlation with age (r(48)=0.23, p=0.1). However, when assessing these correlations in each group separately, activation in the vACC ROI sphere correlated significantly with age in TD youth (r(17)=0.464, p=0.045), but not UAS or AS

• GDC-0994 br Consideraciones finales Al respecto hay que reco

  2018-11-09

  

  Consideraciones finales Al respecto hay que recordar que este problema de vulnerabilidad a los ciclos económicos externos orientó buena parte de los esfuerzos de la política económica aplicada en nuestro país durante varias décadas del siglo xx, sobre todo a partir de las décadas de los años trei

• The following are the supplementary data

  2018-11-09

  

  The following are the supplementary data related to this article. Author Contributions Conflicts of Interest Acknowledgments This work was supported by grant R01 AI098132 (R.L.G.) awarded by the National Institute of Allergy and Infectious Diseases. The transgenic mouse and DNA sequencing

• The bioenergetic system of the brain

  2018-11-09

  

  The bioenergetic system of the GS-9620 is compromised early in the progression of AD and is evident during the prodromal (preclinical) stage of the disease (Mosconi, 2005; Mosconi et al., 2006, 2009b; Reiman et al., 1996, 2004; Yao et al., 2009, 2011b; Brinton et al., 2015; Moreira et al., 2006; Li

• Dietary calcium intake is critical for the calcium homeostas

  2018-11-08

  

  Dietary calcium intake is critical for the calcium homeostasis of bone. Supplementary diets containing calcium with average recommended dietary allowance for children increase bone mineral density (BMD) and reduce the risk of fracture [93]. As reviewed in the previous section, calcium homeostasis is

• br Acknowledgments br Introduction Mouse

  2018-11-08

  

  Acknowledgments Introduction Mouse embryonic stem (ES) ampar can give rise to all somatic cell types and germ cells in a regulative manner and are thereby defined as pluripotent. They are thought to have ‘no pre-determined programme’. However, whether or not an ES cell represents a ‘tabula ra

• It is evident that within our

  2018-11-08

  

  It is evident that within our model, compressed collagen gels play a key role in driving limbal stem cell growth and phenotype. Our results suggest that these changes are due to the increased mechanical properties of compressed collagen gels with improved surface nanostructure. More importantly LEC

• br Material and methods br

  2018-11-08

  

  Material and methods Acknowledgments We are grateful to D. Trono (Lausanne, Switzerland) for the plasmid pMD2.G and psPAX2. We thank Brigitte Jenewein for her excellent technical assistance with the confocal laser-scanning microscopy and the flow cytometry analysis. This work was supported by

15949 records 1043/1064 page Previous Next First page 上5页 10411042104310441045 下5页 Last page