• Long marginalised as a disorder

  2019-05-17

  

  Long marginalised as a disorder confined to specific racial groups, sickle-cell disease is now assuming its rightful place as a major global public health problem. Most patients in the Americas, the Caribbean, and much of Europe have been of one racial group, which led to the common misconception th

• Any abnormality causing a loss of function

  2019-05-16

  

  Any abnormality causing a loss-of-function in the IKs macromolecular complex may lead to adrenergic-induced imbalance in ventricular repolarization currents and consequent QTc prolongation, which is identified based on the defective response of IKs to PKA stimuli due to mutations in KCNQ1 (-G269S, -

• naloxone hydrochloride El n mero de ofrece en una primera se

  2019-05-16

  

  El número 62 de ofrece, en una primera sección, tres artículos que se ubican en los campos de la literatura, las revistas culturales y en general las redes intelectuales en América Latina. Lucía Di Salvo León y Patricio Herrera González, en “¿Una poética del exilio? La revista y el exilio republica

• At baseline the patient exhibited normal A

  2019-05-16

  

  At baseline, the patient exhibited normal A–H (57ms) and H–V (44ms) intervals, with a sinus moexipril length of 784ms. Both antegrade and retrograde dual atrioventricular (AV) nodal physiologies were assessed by atrial and ventricular extrastimulus (Fig. 2), without inducible AV nodal reentrant tac

• Introduction Classically increased cardiac fibrosis has

  2019-05-16

  

  Introduction Classically, increased cardiac fibrosis has been shown to be associated with altered cardiac conduction, causing conduction slowing, block, and reentry in studies on isolated animal and diseased human cardiac tissues [1–3]. Interestingly, similar findings were also demonstrated in isol

• Bisphosphonates are the cornerstone of management in postmen

  2019-05-16

  

  Bisphosphonates are the cornerstone of management in postmenopausal osteoporosis with randomised trial evidence of reductions in vertebral fractures for ibandronate [15] and both vertebral and non-vertebral fracture rates for alendronate [16], risedronate [17], and zoledronic Amyloid Beta-peptide (2

• Eastern European countries have undergone many

  2019-05-16

  

  Eastern European countries have undergone many socioeconomic changes in the past two decades. In particular, in Russia, alcohol was strongly associated with adult mortality. More than half of deaths in Russian men are attributable to cardiovascular disease, with hypertension, hypercholesterolaemia,

• Prior case reports have described hematological remission in

  2019-05-15

  

  Prior case reports have described hematological remission in patients with myelofibrosis during treatment with bisphosphonates, but a phase II study investigating the effects of zoledronic tachykinin receptor on patients with myelofibrosis showed responses in only 1 of 16 patients[13]. In conclusi

• Atrial fibrillation is the most common

  2019-05-15

  

  Atrial fibrillation is the most common atrial arrhythmia studied in BrS [3–14]. The prevalence of AF has been reported to be higher in patients with BrS than in the general d-glucose of the same age [15,16]. Earlier studies reported an approximately 10–50% prevalence of spontaneous, clinical AF in

• La an cdota dialoga con el

  2019-05-15

  

  La anécdota dialoga con el acto de traducción que Mier y Rodríguez realizan de la novela de Chateaubriand y, de hecho, pueden pensarse, gracias a la disposición que Mier les da en el mismo capítulo de su escrito, como actos análogos que implican la toma de posesión y desviación de la voz del extranj

• br Discussion HIV testing and linkage to care are

  2019-05-15

  

  Discussion HIV testing and linkage to care are essential for fighting the HIV epidemic, and evidence-based methods for increasing coverage of testing and accelerating linkage to care are needed. We report that abbreviated counselling was as effective as full length counselling in reducing sexual

• Intimate partner violence is highly prevalent in sub Saharan

  2019-05-15

  

  Intimate partner violence is highly prevalent in sub-Saharan Africa and its role in increasing women\'s risk of HIV acquisition is well recognised, although many aspects of the mechanisms through which HIV increases women\'s risk remain unclear. The most important challenge for researchers is to dev

• Para garantizar la aplicaci n y

  2019-05-15

  

  Para garantizar la aplicación y permanencia de las reformas emprendidas, se necesitaba de un marco normativo institucional que brindara estabilidad al modelo, emitiendo señales de confianza al capital transnacional y otros actores privados que invertían en Perú. La Constitución de 1993, elaborada po

• All patients engrafted patient Patient

  2019-05-15

  

  All patients engrafted; 1 patient (Patient 6) developed secondary graft rejection following an A antigen mismatched graft from a male sibling and went on to receive a VUD HSCT with a female donor. There were no major conditioning related toxicities. Bacterial infections occurred in 6 patients prior

• br Since the publication of Stillbirths Series in

  2019-05-15

  

  Since the publication of Stillbirths Series in 2011, attention to the more than 2·6 million stillbirths that occur every year has become more visible in global and national maternal and neonatal health strategies. However, we continue to neglect the millions of women who experience not only still

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