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The increase observed for the sub indices related
2018-11-15
The increase observed for the sub-indices related to the stages of planning and negotiation (SI), approval (SII) and execution of the budget (SIII) over the period of analysis did not change the relative position of these sub-indices with respect to fiscal discipline: the budgetary institutions that
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We found that the STX R Q variant has
2018-11-15
We found that the STX1 R/Q variant has decreased phosphorylation of Ser14, a key residue involved in the functional regulation of STX1 (Khelashvili et al., 2012; Dubois et al., 2002). STX1 in this hypo-phosphorylated state fails to support DAT-mediated reverse transport of DA without inhibiting DA u
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br Introduction The epidermal permeability
2018-11-15
Introduction The epidermal permeability barrier is one of the most crucial protective functions of the skin and is primarily mediated by stratum corneum lipids and differentiation-related proteins. Stratum corneum lipids consist mainly of an equal molar ratio of cholesterol, fatty acids, and cera
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br Introduction The elderly population in Turkey has now bec
2018-11-15
Introduction The elderly compund w in Turkey has now become the “aged” population. In Turkey, the elderly create 7.7% of the total population, and, according to population projections, this proportion will reach 10.2% (8.6 million older people) in 2023. Materials and methods Multiple compari
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br Acknowledgments br Introduction Psoriatic skin lesions ar
2018-11-15
Acknowledgments Introduction Psoriatic skin lesions are characterized by histological evidence of inflammation, abnormal keratinocyte proliferation/terminal differentiation, and dermal angiogenesis. Although the etiology of psoriasis remains unknown, it is clear that an interaction among genet
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br Hyperimmunoglobulin E syndrome HIES Job s Syndrome is a
2018-11-15
Hyperimmunoglobulin E syndrome (HIES, Job\'s Syndrome) is a rare primary immunodeficiency disease characterized by a clinical triad of recurrent staphylococcal abscesses, pneumonia, and pneumatoceles, with a tendency for recurrent pyogenic infections and elevation of serum immunoglobulin E (IgE) l
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In conclusion the results of this study suggest
2018-11-15
In conclusion, the results of this study suggest that daily supplementation of curcumin extracts has a positive beneficial effect against chemically induced colonic preneoplastic progression in rats induced by DMH, which provide an effective dietary chemopreventive approach to disease management. Be
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Finally by sorting the Wnt off cells we obtained a
2018-11-14
Finally, by sorting the “Wnt-off” cells, we obtained a striking increase in the number of reprogrammed NANOG+ clones, thus clearly identifying the “Wnt-off” state as an early reprogramming marker. It is interesting to note how different the roles of TCF3 and TCF1 are in the control of somatic cell
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The inhibition of differentiation has been considered
2018-11-14
The inhibition of differentiation has been considered to play a role in many types of tumor development through maintenance of the proliferating progenitor cell state. Previous studies demonstrated that the knockdown of EWS-FLI1 in Ewing sarcoma cell lines results in osteogenic, adipogenic and chond
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br Authors Contributions br Conflict of Interest
2018-11-14
Authors\' Contributions Conflict of Interest Jeri Kim, MD, acknowledges receipt of nonfinancial support from Merck, which provided 5-mg tablets of finasteride and matching placebos for the study. For the 3years preceding submission, she has no other conflict of interest to report. Ian Thompson
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Some of the identified signals can be attributed to
2018-11-14
Some of the identified signals can be attributed to confounding by indication. This is most notable for the observed associations with lung cancers. As an example, drugs used to treat obstructive lung diseases exhibited a strong association with squamous cell carcinoma of the lung (OR, 2.61), which
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Several lines of evidence implicate VPS retromer
2018-11-14
Several lines of evidence implicate VPS35/retromer in bone remodeling or bone homeostasis. First, VPS35 is highly expressed in both OB- and OC-lineage purchase Madecassoside (Xia et al., 2013b). Second, VPS35/retromer\'s cargos, such as PTH1R, Wntless, and RANK, are critical for bone remodeling or
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The mono ubiquitination lysosome system
2018-11-14
The mono-ubiquitination-lysosome system degrades the majority of cell surface receptors including GPCRs (Marchese and Trejo, 2013; Marchese et al., 2003; Shenoy et al., 2008; Henry et al., 2012; Xiao and Shenoy, 2011). Three enzyme complexes (E1, E2, and E3) are involved in protein ubiquitination. E
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B cell activation including the activation of
2018-11-14
B cell activation, including the activation of pre-existing memory B cells (MBC), contributes to a substantial plasmablast response during acute heterologous infection [7–9], resulting in a high increase in neutralizing antibody titers [10] that contribute to temporary cross-protection against all f
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The progression of a GBM depends on invasive growth
2018-11-14
The progression of a GBM depends on invasive growth marked by mesenchymal cell features. It therefore remains a critical priority to expand our knowledge of how the mesenchymal features are modulated. We have employed aSICS as an integrative modeling method to identify regulators of cancer subtypes.
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