• br Material and methods br

  2024-08-26

  

  Material and methods Results Discussion GRK2 activity has increasingly been shown to contribute to the progression of numerous diseases and organ dysfunction [5], [6]. For instance, a large body of work over the last two decades has identified GRK2 as a major regulator of cardiac dysfunctio

• Our co IP data show that

  2024-08-26

  

  Our co-IP data show that 5HT1A or 5HT2A receptors do not heterodimerize with mGluR1α receptors. Given that both 5-HT and mGlu receptors are GPCRs and produce anxiolytic effects, a degree of cooperativity via a functional cross-talk may still exist between these receptors [11]. In addition to the fun

• We observed PACAP immunoreactivity in

  2024-08-26

  

  We observed PACAP2 immunoreactivity in the molecular layer of the cerebellar cortex in zebrafish. This result is consistent with the reporting of PACAP immunoreactivity in the soma and fibers of Purkinje cells and the presence of PACAP mRNA in the Purkinje-cell and granular-cell layers in rats [43].

• ACK has been clearly implicated in

  2024-08-26

  

  ACK1 has been clearly implicated in cancer progression in recent years. A strong correlation between ACK1 gene copy number, protein level and activity have been demonstrated in tumors of different tissue types (Mahajan et al., 2007; van der Horst et al., 2005; Wang et al., 2006). Our western blot an

• br Conflicts of interest br Acknowledgments br Significance

  2024-08-26

  

  Conflicts of interest Acknowledgments Significance Introduction Androgen receptor (AR) plays a paramount role in the onset and progression of prostate cancer (PC) (Burnstein, 2005, Lonergan and Tindall, 2011, Watson et al., 2015). This very facet underlies androgen deprivation therapy (A

• Whereas more research is needed to identify

  2024-08-26

  

  Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the Urolithin A that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely reversed the beh

• The synthesis and secretion of

  2024-08-26

  

  The synthesis and secretion of adrenal androgens is apparently unique to humans and nonhuman primates, and requires the expression of key mediators such as CYP17 [26]. Endocrine control of CYP17 expression in rhesus monkeys is comparable to that in humans [27]. An analysis of baboon cDNA for CYP17 s

• br Conclusion br List of abbreviations

  2024-08-26

  

  Conclusion List of abbreviations Acknowledgment The studies performed by our laboratory and presented in this review were supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan, (KAKENHI 17590618 [to H.I.] and KAKENHI 22249017 [to Y.Y.]), and the Japanese S

• For the TSH receptor signaling at

  2024-08-23

  

  For the TSH receptor, signaling at the Golgi/trans-Golgi network appears required for both rapid effects of TSH − such as 7915 depolymerization, which is implicated in thyroglobulin reuptake and, thus, thyroid hormone release − and late ones, such as those on gene transcription. Continued signaling

• AP was originally described as a heterodimer of the bZIP

  2024-08-23

  

  AP-1 was originally described as a heterodimer of the bZIP proteins c-Jun and c-Fos. The experiments described here showed that stimulation of TRPV1 channels induced the expression of both of these classical constituents of AP-1. The essential role of both proteins was analyzed in a series of experi

• There is a growing body of evidence showing that

  2024-08-23

  

  There is a growing body of evidence showing that pentobarbital causes memory disorders [3], [4], [5]. Our results that a single injection of pentobarbital into bilateral hippocampus significantly impaired hippocampus-dependent spatial memory retrieval (Fig. 1) add support to that evidence. Previous

• The control group participants of the

  2024-08-23

  

  The control group participants of the current study were very similar in age to those of Puertas et al. There was no significant correlation between age and enzyme activity over the short age span studied although age-related changes in the activity of ApA and aspartyl aminopeptidase, typically incr

• The present study determined the effect of DCA on

  2024-08-23

  

  The present study determined the effect of DCA on VSMC calcification in vitro and in atherosclerotic ApoE-/- mice in vivo. We found that ana 2 non-toxic concentrations of DCA, did not affect VSMC viability, induced calcification of VSMC in culture and increased atherosclerotic vascular calcificatio

• The first rationally designed dual

  2024-08-22

  

  The first rationally designed dual mPGES-1/5-LO inhibitor was reported in 2008 and represents a structural derivative of pirinixic bapta am - a synthetic agonist of PPARα with lipid-lowering properties (Koeberle et al., 2008b). Further α-alkyl- and α-aryl-substituted derivatives have been synthesiz

• br Role of LPA in tumor angiogenesis and skeletal metastasis

  2024-08-22

  

  Role of LPA in tumor angiogenesis and skeletal metastasis The angiogenesis switch is essential for tumor expansion and escape of tumor MLN 9708 from the primary site and forming distant metastases. Evidence for the role of LPA2 and LPA3 in the mobility of endothelial cells and the formation of n

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