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A number of studies have been carried out
2020-05-11
A number of studies have been carried out to understand lipid production pathways and to increase TAGs level in higher plants. Overexpression of key nrf2 inhibitor of the Kennedy pathway until now is by far the most successful strategy to increase TAG lipid content in Brassica napus, Arabidopsis th
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her2 inhibitor br Conclusions This study showed that in EOC
2020-05-11
Conclusions This study showed that in EOC cells, tyrosine kinase receptor DDR1 was expressed mainly in EOC her2 inhibitor with an Epithelial phenotype. The repressed expression of DDR1 in EOC cells with Mesenchymal phenotype could be due to the higher CpG methylation levels observed at the promo
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br Cysteine proteases as molecular targets for trypanosomati
2020-05-11
Cysteine proteases as molecular targets for trypanosomatid diseases Approaches relying on a molecular target, such as SBDD and target-based screening, have supported outstanding scientific developments in current pharmaceutical R&D. By integrating experimental and computational methods, these str
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Previous studies revealed the expression of the CCR
2020-05-11
Previous studies revealed the expression of the CCR3 receptor in neurons and its neuroprotective function using mice lacking CCR3 expression (Wainwright et al., 2009). The regulation of CCR3 receptor expression in the microglia and astrocytes was shown in neurological disorders and has been demonstr
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Recently several Pt IV complexes as prodrugs
2020-05-11
Recently, several Pt(IV) complexes as prodrugs have been designed and studied to enhance anti-tumor efficacy of traditional Pt(II) drugs, improving their cellular uptake and blood-circulation time [26], [27], [28], [29]. Compared with their Pt(II) counterparts, six-coordinated Pt(IV) complexes with
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br Acknowledgements br Introduction Protein tyrosine phospho
2020-05-11
Acknowledgements Introduction Protein–tyrosine phosphorylation, catalyzed by protein–tyrosine kinases and protein–tyrosine phosphatases, has a pivotal role in the regulation of a wide variety of cellular processes. Similar numbers of tyrosine kinases and tyrosine phosphatases are encoded by th
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br Conclusion br Declaration of
2020-05-11
Conclusion Declaration of interest Introduction Glyphosate [N-(phosphonomethyl)glycine] is the main active ingredient in one of the most widely used herbicides in the world. The commercially used concentrations of glyphosate range from 1% for domestic use to 41% for conventional agricultura
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Our study shows that deletion of
2020-05-11
Our study shows that Betaine mg of Dpf2 in mouse ESCs decreased their self-renewal ability and dramatically impaired their differentiation into mesoderm and endoderm while promoting neural ectoderm differentiation. The differentiation defect to meso-endoderm could be rescued by restoring Tbx3 level
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CID 755673 br Ultrasonic pretreatment of substrates Substrat
2020-05-11
Ultrasonic pretreatment of substrates Substrate pretreatment is widely used in the biofuel, textile and food industries since the substrates are always difficult to degrade. During some enzymatic hydrolysis reactions, the protective layer of the substrate impedes the reaction. Ultrasonic treatmen
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In general we observed that the enolase gene with highest
2020-05-11
In general, we observed that the enolase gene with highest mRNA levels was TVAG_043500, under all three iron concentration conditions. mRNA levels for this gene are very similar in normal and iron rich cultures (73.9 and 78.1 fold change, respectively), and higher in iron depleted cultures (118.3 fo
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In conclusion this study indicated that D tripetala and
2020-05-09
In conclusion, this study indicated that D. tripetala and A. melengueta extracts inhibited CYP 3A enzyme both in vitro and in vivo. Although these inhibitions may appear to be weak from the US FDA classification point of view, caution must be applied in the concurrent use of herbal preparations cont
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We also observed reduced insulinotropic effects
2020-05-09
We also observed reduced insulinotropic effects after intravenous administration of both GLP-1 and GIP with atropine, whereas no inhibition was observed by atropine of the direct effects of GLP-1 and GIP action on beta-cells in the islet experiments. This suggests that the reduction in circulating i
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In studies directed toward the development of sequence
2020-05-09
In studies directed toward the development of sequence-specific major-groove binding small tranylcypromine [11], we desired a non-intercalating molecular scaffold that could direct attached moieties into the major groove. As an initial step toward this goal, we wished to study the DNA binding mode
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In Arabidopsis the quartet qrt mutant enables the same
2020-05-09
In Arabidopsis the quartet1 (qrt1) mutant enables the same type of analysis of gametophytes (pollen) in sets of four (tetrads) derived from individual meioses 61., 62.. Pollen tetrads from one accession (Columbia-0) are used to pollinate a second polymorphic accessions (Landsberg erecta) resulting i
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The cysteinyl leukotrienes cysLTs LTC LTD and LTE are
2020-05-09
The cysteinyl leukotrienes (cysLTs) LTC, LTD, and LTE are increased in the airways of asthmatic subjects, with the ability to induce bronchoconstriction, vascular permeability, and mucus secretion., , , , CysLTs are well established as mediators of allergic rhinitis and asthma on the basis of the e
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