• Since the late s synthetic GC e g

  2022-04-19

  

  Since the late 1940s, synthetic GC (e.g. prednisone, prednisolone, dexamethasone) have been used extensively in the treatment of chronic inflammatory conditions such as rheumatoid arthritis and asthma, and for their immunosuppressant action in preventing organ rejection post transplantation. Cortico

• Genetic disruption or pharmacologic inhibition of

  2022-04-19

  

  Genetic disruption or pharmacologic inhibition of the hepatic glucagon pathway has invariably been shown to increase pancreatic α cell mass. This has been observed in glucagon receptor (GCGR) knockout (Gcgr−/−) mice (Gelling et al., 2003), glucagon knockout mice (Hayashi et al., 2009), prohormone co

• The general aim of our in vitro experiments

  2022-04-19

  

  The general aim of our in vitro experiments was to analyze the patterns of ghrelin and GHSR-1a expression in the mammary glands of dairy goats during pregnancy and to examine the direct effect of ghrelin on cell proliferation in cultured MECs of pregnant dairy goats. For this purpose, we cultured go

• Efavirenz Ghrelin receptors in non mammals

  2022-04-19

  

  Ghrelin receptors in non-mammals are reportedly more “complicated/complex and diverse” than in mammals, having additional paralogs and splice variants (Kaiya et al., 2014). Several teleost fish GHS-Rs have been identified; however, functional characterization has been conducted in only a few (see, K

• br Signals transmitted via MEGJ MEGJ facilitate the direct t

  2022-04-19

  

  Signals transmitted via MEGJ MEGJ facilitate the direct transfer of ion currents or small molecules between EC and VSMC. Molecules passing through MEGJ are mainly second messengers such as Ca2+, IP3, and cAMP [31,32,] or endothelium-derived hyperpolarization (EDH) signals [34, 35, 36]. Moreover,

• CHC Cytokines and hormones influence both gap junctions and

  2022-04-19

  

  Cytokines and hormones influence both gap junctions [106] and endocrine activity in the pituitary [3]. Long-term treatment (2 h) with the proinflammatory cytokines interleukin-1β (Il-1β) and tumor necrosis factor-α (TNF-α) transiently increases Cx43 expression and cell coupling in TtT/GF CHC [105]

• br Introduction Conversion of visual input into electrical i

  2022-04-19

  

  Introduction Conversion of visual input into electrical information and routing this information to the brain is the main function of the eye (Levin et al., 2011). These processes require a microenvironment that offers adequate supply with oxygen and nutrients and also removal of all unwanted and

• Determination of enzyme activity differs from other analytic

  2022-04-19

  

  Determination of enzyme activity differs from other analytical procedures. In this beta lactamase inhibitor case, instead of enzyme concentration, a substrate depletion or product accumulation should be monitored. Such approach allows calculating activity basis of calibration curves performed for en

• We next determined the selectivity profile of

  2022-04-19

  

  We next determined the selectivity profile of the most potent GPR40 agonists (4k–n) against other free fatty signal transducer and activator of transcription 6 fragment sale receptors (FFA3/GPR41, FFA2/GPR43 and FFA4/GPR120). FFA2 and FFA3 agonists have a preference in binding short-chain fatty aci

• Receptor tyrosine kinases RTKs consist of subfamilies in hum

  2022-04-19

  

  Receptor tyrosine kinases (RTKs) consist of 20 subfamilies in humans, all of which share a common structure consisting of extracellular ligand-binding region, a single-pass transmembrane domain and an intracellular tyrosine kinase domain [2]. Binding of a growth factor to the ligand-binding domain r

• Collectively these observations demonstrate that FAAH is fun

  2022-04-19

  

  Collectively, these observations demonstrate that FAAH is functionally positioned to modulate the actions of AEA and other NAEs on BLA neurons and anxiety processes mediated by this region. By extension, manipulations that lead to alterations in FAAH activity, such as stress or administration of com

• Aberrant activity of PRC as a result of over expressed

  2022-04-19

  

  Aberrant activity of PRC2 as a result of over expressed EZH2, has been frequently seen in a wide range of human cancers including breast and prostate tumors [10]. However, leukemia-associated epigenetic aberrations are not fully understood [7]. Herein, we will overview the current knowledge of epige

• Our understanding of the genetic basis

  2022-04-19

  

  Our understanding of the genetic basis of myeloid malignancies has been profoundly improved in recent years. Studies have revealed new recurrent somatic mutations in myeloid malignancies, including myeloproliferative neoplasms (MPNs), myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML).

• Within a live organism cells need to transfer information to

  2022-04-19

  

  Within a live organism, cells need to transfer information to each other. Exocytosis is one of the critical mechanism which releases variety of ligands into the extracellular space. When cells export material via exocytosis, they first pack into vesicles, then cause the vesicles to tether at the pla

• It is apparent from the data

  2022-04-19

  

  It is apparent from the data in that none of the ligands exhibits significant toxicity as determined by the viability of human embryonic kidney (HEK 293) cells at a concentration of 100 μM. It is also apparent from the data in and that a number of the ligands inhibit the HIV-1 IN enzyme. However,

16043 records 446/1070 page Previous Next First page 上5页 446447448449450 下5页 Last page